In Vitro Studies

To further elucidate the mechanisms of HMB, Cheng et al investigated the effects of HMB on fatty acid uptake and oxidation in two different muscle cell lines, derived from heart and skeletal muscle. Their research indicated that beta-oxidation increased about 30% following the incubation of muscle cells in a medium containing HMB. The exact mechanism as to how HMB influences fat oxidation is unknown. Also what is unknown is whether the in vitro research will be verified in animals and humans.

Human Studies

A single human study investigating the effects of HMB on body composition has been published in a peer-reviewed journal. In this study, they reported a significant increase in fat-free mass, but not a significant drop in body fat compared with the placebo. In the same reference, the authors reported that another group of subjects did not experience a decline in fat mass during a 7 -week treatment with HMB. Although research is limited, it seems unlikely that HMB affects lipid oxidation in humans.

Safety and Toxicity

The safety data for HMB are impressive. Every HMB study that has been funded by either Metabolic Technologies, Inc. or by Experimental and Applied Sciences, Inc. has included safety data. Although the longest human study to date is 8 weeks long, it appears that HMB has no adverse reactions. Animal studies report that dosages greater than 100 times the normal human dose do not result in any changes in blood chemistry and hematology measurement in pigs. Furthermore, there were no effects of HMB on gross organ pathology and histology. Longer-term studies are needed to determine how the body responds to chronic consumption of HMB over a period of a year or more. But for now one can confidently say that HMB is one of the safest dietary supplements on the market.

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